1-Isocyanato-2-(methylsulfanyl)benzene → N-(2-hydroxy-4-nitro phenyl) N'-(2-methylthio phenyl) urea

HRID 567988Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 567988
[OH:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH3:12][S:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N:20]=[C:21]=[O:22]>>[OH:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH:4][C:21]([NH:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[S:13][CH3:12])=[O:22]

Komponenten

3

Edukt 2

HCID 27369891-Isocyanato-2-(methylsulfanyl)benzeneHCID 49847212-Amino-5-Nitrophenol

Produkt 1

HCID 9840030N-(2-hydroxy-4-nitro phenyl) N'-(2-methylthio phenyl) ureaAusbeute 61 %

Versuchsvorschrift

The urea was prepared from 2-hydroxy 4-nitro aniline (500 mg, 3.24 mmol) and 2-methylthio phenylisocyanate(3.24 mmol) by general Method B. The product was purified by dilution with methylene chloride and precipitation with hexanes. Filtering afforded the title compound(0.63 g, 61%). EI-MS m/z 320(M+H)+.

Aufarbeitung

  1. customThe product was purified by dilution with methylene chloride and precipitation with hexanes
  2. filtrationFiltering

Quellen und Nachweise

ORD-Eintrag
ord-57ec021ffb6b42af9c4de63e9d7494a2
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06180675B2

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