Acetonitrile → 2-Thenoylacetonitrile

HRID 568589

Reaktionsgleichung

Reaktionsgleichung von HRID 568589
C(O[C:4]([C:6]1[S:7][CH:8]=[CH:9][CH:10]=1)=[O:5])C.[H-].[Na+].[C:13](#[N:15])[CH3:14]>C1(C)C=CC=CC=1>[S:7]1[CH:8]=[CH:9][CH:10]=[C:6]1[C:4]([CH2:14][C:13]#[N:15])=[O:5]

Komponenten

5

Edukt 3

HCID 6342AcetonitrileHCID 24758Sodium hydrideHCID 76052Ethyl 2-thenoate

Produkt 1

HCID 1418532-ThenoylacetonitrileAusbeute 92,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

78.1 grams (0.5 mole) of thiophene-2-carboxylic acid ethyl ester and 30 grams (1 mole) of sodium hydride (80% suspension in white oil) were reacted with 41.5 grams (1 mole) of acetonitrile in 500 ml of dry toluene. There were obtained 70.0 grams (92.6% of theory) of 2-thiophenoylacetonitrile having a melting point of 110° C.

Quellen und Nachweise

ORD-Eintrag
ord-6134339ac3da40398099f92e3039b85c
Quelldatensatz
uspto-grants-1988_03
Patentnummer
US04728743

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