Phthalimide → HCID 20149445, Verbindung

HRID 568987Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 568987
O[CH:2]([CH2:5][CH2:6][C:7]([F:23])([F:22])[CH:8]([N:11]1[C:15](=[O:16])[C:14]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:13]2[C:12]1=[O:21])[CH:9]=[CH2:10])[CH:3]=[CH2:4].[C:24]1(=[O:34])[NH:28][C:27](=[O:29])[C:26]2=[CH:30][CH:31]=[CH:32][CH:33]=[C:25]12.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>O1CCCC1>[C:24]1(=[O:34])[N:28]([CH:2]([CH2:5][CH2:6][C:7]([F:23])([F:22])[CH:8]([N:11]2[C:15](=[O:16])[C:14]3=[CH:17][CH:18]=[CH:19][CH:20]=[C:13]3[C:12]2=[O:21])[CH:9]=[CH2:10])[CH:3]=[CH2:4])[C:27](=[O:29])[C:26]2=[CH:30][CH:31]=[CH:32][CH:33]=[C:25]12

Komponenten

6

Edukt 4

HCID 6809PhthalimideHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 20149486HCID 20149486, Verbindung

Produkt 1

HCID 20149445HCID 20149445, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 3-hydroxy-6,6-difluoro-7-phthalimido-1,8-nonadiene (148 mg, 0.46 mmoles), phthalimide (73.5 mg, 0.5 mmoles), triphenylphosphine (131.5 mg, 0.5 mmoles) and diethyl azodicarboxylate (73 l, 0.6 mmoles) in tetrahydrofuran (5 ml) is kept under nitrogen at 25° C. for 20 hours. After concentration under reduced pressure, the title compound is obtained after purification by chromatography on silica (dichloromethane, RF: 0.43): 95 mg (46%).

Aufarbeitung

  1. concentrationAfter concentration under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f32b1760e7c0413f85497921899d8062
Quelldatensatz
uspto-grants-1988_03
Patentnummer
US04730006

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