HCID 54347464, Verbindung → HCID 53945839, Verbindung

HRID 569087Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 569087
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[C:18]=1[CH3:19])=[C:15]([CH:20]=[CH:21][N+:22]([O-])=O)[CH:14]=[CH:13][CH:12]=3)=[O:5])[CH3:2]>C(O)C.[H][H].S(=O)(=O)(O)O.[C].[Pd]>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[C:18]=1[CH3:19])=[C:15]([CH2:20][CH2:21][NH2:22])[CH:14]=[CH:13][CH:12]=3)=[O:5])[CH3:2]

Komponenten

6

Edukt 1

HCID 54347464HCID 54347464, Verbindung

Produkt 1

HCID 53945839HCID 53945839, VerbindungAusbeute 65,6 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel2×HCID 1118Sulfuric AcidLösungsmittelHCID 178418361HCID 178418361, VerbindungLösungsmittel

Versuchsvorschrift

5-(2-Nitrovinyl)-4-methyl-beta-carboline-3-carboxylic acid ethyl ester (1 g) is dissolved in ethanol (20 ml) and in a hydrogen atmosphere with stirring is slowly added drop by drop to a suspension of 10% palladium carbon (0.25 g) in ethanol (50 ml) and sulfuric acid (0.1 ml). In the end, it is stirred for another half hour more. Then the catalyst is suctioned off and the filtrate evaporated. After the usual working up, 0.6 g of the title compound is obtained.

Aufarbeitung

  1. stirringIn the end, it is stirred for another half hour more
  2. customthe filtrate evaporated

Quellen und Nachweise

ORD-Eintrag
ord-9edca75d84c64d9cba7de3a1d4dc10e6
Quelldatensatz
uspto-grants-1988_03
Patentnummer
US04731365

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