Hydrochloric Acid → 3-Cyano-2-oxo-8-chromenyloxyacetic acid

HRID 569091

Reaktionsgleichung

Reaktionsgleichung von HRID 569091
S1CCCC1.[Br-].[Al+3].[Br-].[Br-].C[O:11][C:12](=[O:28])[C:13]([O:15][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:25]=1[O:24][CH2:23][C:22]([C:26]#[N:27])=[CH:21]2)=[O:14].Cl>CCl>[C:26]([C:22]1[CH2:23][O:24][C:25]2[C:20]([CH:21]=1)=[CH:19][CH:18]=[CH:17][C:16]=2[O:15][C:13](=[O:14])[C:12]([OH:28])=[O:11])#[N:27]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 1127TetrahydrothiopheneHCID 166749BromhydrolHCID 703534933-Cyano-2-oxo-8-chromenyloxyacetic acid methyl ester

Produkt 1

HCID 703539353-Cyano-2-oxo-8-chromenyloxyacetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6327Methyl ChlorideLösungsmittel

Versuchsvorschrift

Ten ml of tetrahydrothiophene was cooled with ice, to which 13.4 g of pulverized anhydrous aluminium bromide was gradually added. After stirring for 5 minutes, a temperature was brought to room temperature and then a solution of 2.6 g of 3-cyano-2-oxo-8-chromenyloxyacetic acid methyl ester dissolved in 30 ml of methyl chloride was gradually added. After stirring for 2 hours, the reaction mixture was poured into a mixture of 20 ml of concentrated hydrochloric acid and 200 ml of ice water and a precipitate was filtered, which was recrystallized to give a desired compound.

Aufarbeitung

  1. additionwas gradually added
  2. customwas brought to room temperature
  3. additionwas gradually added
  4. stirringAfter stirring for 2 hours
  5. filtrationa precipitate was filtered
  6. customwhich was recrystallized

Quellen und Nachweise

ORD-Eintrag
ord-057f1541b9894369866bc9da13bbcf5d
Quelldatensatz
uspto-grants-1988_03
Patentnummer
US04731375

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