Trifluoroacetic acid → HCID 117622495, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:32][CH:33]([F:35])[F:34])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:24][CH2:25][O:26][C:27]([F:30])([F:29])[F:28])[C:17]([O:19]C(C)(C)C)=[O:18])[C:10](=[O:31])[CH:9]=2)[CH:7]=1.C(O)(C(F)(F)F)=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:32][CH:33]([F:34])[F:35])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:24][CH2:25][O:26][C:27]([F:30])([F:29])[F:28])[C:17]([OH:19])=[O:18])[C:10](=[O:31])[CH:9]=2)[CH:7]=1Komponenten
3
Versuchsvorschrift
327 mg (0.62 mmol) of tert-butyl 2-{4-[5-chloro-2-(difluoromethoxy)phenyl]-5-methoxy-2-oxopyridin-1(2H)-yl}-4-(trifluoromethoxy)butanoate (racemate) were hydrolysed with TFA according to General Method 6A. Yield: 290 mg (purity 93%, 92% of theory)
Quellen und Nachweise
- ORD-Eintrag
- ord-3f34c8ad5ff44b6dac80e0a322daaace
- Quelldatensatz
- uspto-grants-2016_09
- Patentnummer
- US09434690B2
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