Potassium Carbonate → 2-(Oxiran-2-yl)benzene-1-sulfonamide

HRID 569455

Reaktionsgleichung

Reaktionsgleichung von HRID 569455
[CH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([NH2:12])(=[O:11])=[O:10])=[CH2:2].C(=O)([O-])[O-:14].[K+].[K+]>C(Cl)(Cl)Cl>[O:14]1[CH2:2][CH:1]1[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([NH2:12])(=[O:10])=[O:11]

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 113674032-Ethenylbenzenesulfonamide

Produkt 1

HCID 138845232-(Oxiran-2-yl)benzene-1-sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A solution consisting of 2-ethenylbenzenesulfonamide (1.5 g, 8.1 mmol) m-chloroperbenzoic acid (1.4 g, 8.1 mmol) and potassium carbonate (1.1 g, 8.1 mmol) in 150 ml of chloroform was stirred for 4 days at room temperature. The reaction was filtered and the filtrate was washed with saturated sodium bicarbonate. The organic layer was separated, dried and concentrated. The resulting oil was flash chromatographed (methylene chloride) to yield the subject compound as a white solid, m.p. 136°-139° C.

Aufarbeitung

  1. filtrationThe reaction was filtered
  2. washthe filtrate was washed with saturated sodium bicarbonate
  3. customThe organic layer was separated
  4. customdried
  5. concentrationconcentrated
  6. customchromatographed (methylene chloride)

Quellen und Nachweise

ORD-Eintrag
ord-61218c3e69fa460da834ee153f38e71b
Quelldatensatz
uspto-grants-1988_03
Patentnummer
US04732604

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