Chloroform → 1-Bromo-2-(2,2-Dichlorocyclopropyl)benzene

HRID 569456

Reaktionsgleichung

Reaktionsgleichung von HRID 569456
[OH-].[Na+].[Br:3][C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH:6]=[CH2:7].[CH:12]([Cl:15])(Cl)[Cl:13]>>[Br:3][C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH:6]1[CH2:7][C:12]1([Cl:15])[Cl:13]

Komponenten

4

Edukt 3

HCID 6212ChloroformHCID 14798Sodium HydroxideHCID 162642-Bromostyrene

Produkt 1

HCID 138845251-Bromo-2-(2,2-Dichlorocyclopropyl)benzene

Reaktionsbedingungen

Temperatur
45 °C

Versuchsvorschrift

A 20 ml solution of 50% sodium hyroxide was added dropwise to 2-bromostyrene (10.0 g, 54.9 mmol) in 100 ml of chloroform. The reaction mixture was warmed to 45° C. for 1 hour. After cooling the solution was separated and the organic layer was dried over magnesium sulfate and concentrated. The resulting liquid was flash chromatographed, affording 11.6 g of the desired compound.

Aufarbeitung

  1. temperatureAfter cooling the solution
  2. customwas separated
  3. dry with materialthe organic layer was dried over magnesium sulfate
  4. concentrationconcentrated
  5. customchromatographed

Quellen und Nachweise

ORD-Eintrag
ord-b8dcf5ab40e14ccb81f16ed37d0dfda3
Quelldatensatz
uspto-grants-1988_03
Patentnummer
US04732604

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