Hydrochloric Acid → 1-Ethylpiperidine-2,4-dione

HRID 569989Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 569989
C([CH:6]1[C:11](=[O:12])[CH2:10][CH2:9][N:8]([CH2:13][CH3:14])[C:7]1=[O:15])(OCC)=O.Cl>>[CH2:13]([N:8]1[CH2:9][CH2:10][C:11](=[O:12])[CH2:6][C:7]1=[O:15])[CH3:14]

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 13784118Ethyl 1-Ethyl-2,4-dioxopiperidine-3-carboxylate

Produkt 1

HCID 137841191-Ethylpiperidine-2,4-dioneAusbeute 70 %

Versuchsvorschrift

Added to 36.0 g of 3-carboethoxy-1-ethylpiperidine-2,4-dione (Referential Example 35) was 300 ml of a 10% aqueous solution of hydrochloric acid. The resultant mixture was refluxed for 40 minutes. After allowing the reaction mixture to cool down, it was extracted with chloroform. The chloroform layer was washed with water, dried and then concentrated, thereby obtaining 16.6 g of 1-ethylpiperidine-2,4-dione as a light yellowish oily substance (yield: 70%).

Aufarbeitung

  1. temperatureto cool down
  2. extractionit was extracted with chloroform
  3. washThe chloroform layer was washed with water
  4. customdried
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-03264042118a435a924dd981a1008270
Quelldatensatz
uspto-grants-1988_03
Patentnummer
US04734418

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