Piperazine → 2-Piperazino-6,7-dimethoxyquinazoline

HRID 570011Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 570011
Cl[C:2]1[N:11]=[CH:10][C:9]2[C:4](=[CH:5][C:6]([O:14][CH3:15])=[C:7]([O:12][CH3:13])[CH:8]=2)[N:3]=1.[NH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>C(O)CC(C)C>[N:16]1([C:2]2[N:11]=[CH:10][C:9]3[C:4](=[CH:5][C:6]([O:14][CH3:15])=[C:7]([O:12][CH3:13])[CH:8]=3)[N:3]=2)[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1

Komponenten

4

Edukt 2

HCID 4837PiperazineHCID 18181442-Chloro-6,7-dimethoxyquinazoline

Produkt 1

HCID 137841852-Piperazino-6,7-dimethoxyquinazolineAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31260Isoamyl AlcoholLösungsmittel

Versuchsvorschrift

Refluxed for 2 hours in isoamyl alcohol (15 ml) were 0.63 g of 2-chloro-6,7-dimethoxyquinazoline (synthesized by the method described in Japanese Patent Laid-Open No. 36390/1972) and 0.72 g of anhydrous piperazine. Isoamyl alcohol was thereafter distilled off under reduced pressure, followed by extraction with 2N--NaOH and chloroform. The chloroform layer was washed with saturated saline and then dried with anhydrous magnesium sulfate. Chloroform was distilled off under reduced pressure to obtain 0.7 g of the intended product (yield: 91%).

Aufarbeitung

  1. customsynthesized by the method
  2. distillationIsoamyl alcohol was thereafter distilled off under reduced pressure
  3. extractionfollowed by extraction with 2N
  4. washThe chloroform layer was washed with saturated saline
  5. dry with materialdried with anhydrous magnesium sulfate
  6. distillationChloroform was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-021aededadf048898074c8fd46bc7614
Quelldatensatz
uspto-grants-1988_03
Patentnummer
US04734418

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