Dichloromethane → 5-Nitro-2-(2-trifluoromethyl-phenyl)-pyridin-4-ylamine

Temperatur

85 °C

2-Bromo-5-nitropyridin-4-amine (561 mg, 2.57 mmol), Cs2CO3 (2.52 g, 7.72 mmol), (dppf)PdCl2.DCM (113 mg, 0.154 mmol), and 2-(trifluoromethyl)phenylboronic acid (636 mg, 3.35 mmol) were combined and flushed with Ar and anhydrous DME (24 mL) was added. H2O (8 mL) was added via syringe and the resulting mixture was stirred at 85° C. for 18 h. The resulting mixture was cooled to room temperature and diluted with EtOAc (30 mL) and the resulting solution was washed with brine (30 mL). The aqueous phase was extracted with EtOAc (3×25 mL) and the combined extracts were dried over MgSO4 and filtered. The solvent was removed under reduced pressure and the residue was chromatographed on a 40-g SiO2 pre-packed column eluting with 0:1-2:3 EtOAc/hexanes to yield 5-nitro-2-(2-trifluoromethyl-phenyl)-pyridin-4-ylamine. 1H-NMR (400 MHz, CDCl3) δ: 9.17 (s, 1H), 7.70 (d, J=7.8 Hz, 1H), 7.56 (t, J=7.1 Hz, 1H), 7.49 (t, J=7.5 Hz, 1H), 7.40 (d, J=7.6 Hz, 1H), 7.00 (br. s., 2H), 6.71 (s, 1H). Mass Spectrum (LCMS, ESI pos.): Calculated for C12H8F3N3O2: 284.1 (M+H); Measured: 284.1.

1. customflushed with Ar and anhydrous DME (24 mL)
2. additionwas added
3. additionH2O (8 mL) was added via syringe
4. temperatureThe resulting mixture was cooled to room temperature
5. additiondiluted with EtOAc (30 mL)
6. washthe resulting solution was washed with brine (30 mL)
7. extractionThe aqueous phase was extracted with EtOAc (3×25 mL)
8. dry with materialthe combined extracts were dried over MgSO4
9. filtrationfiltered
10. customThe solvent was removed under reduced pressure
11. customthe residue was chromatographed on a 40-g SiO2 pre-packed column
12. washeluting with 0:1-2:3 EtOAc/hexanes

ORD-Eintrag

ord-1b6e27c5d3234688bb566d38ab77f683

Quelldatensatz

uspto-grants-2015_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09023846B2