Reaktionsgleichung
C(OC(N1[CH2:12][CH2:11][CH:10]([NH:13][C:14]([C:16]2[S:17][CH:18]=[CH:19][C:20]=2[NH:21][C:22]2[CH:27]=[CH:26][N:25]=[C:24]3[NH:28][CH:29]=[CH:30][C:23]=23)=[O:15])C1)=O)(C)(C)C.[O:31]1CC[CH2:33][CH:32]1CN>>[O:31]1[CH2:32][CH2:33][CH2:12][CH:11]1[CH2:10][NH:13][C:14]([C:16]1[S:17][CH:18]=[CH:19][C:20]=1[NH:21][C:22]1[CH:27]=[CH:26][N:25]=[C:24]2[NH:28][CH:29]=[CH:30][C:23]=12)=[O:15]Komponenten
3
Versuchsvorschrift
This compound was prepared in an analogous manner as 3-{[3-(1H-Pyrrolo[2,3-b]pyridin-4-ylamino)-thiophene-2-carbonyl]-amino}-pyrrolidine-1-carboxylic acid tert-butyl ester using 1-(tetrahydrofuran-2-yl)methaneamine instead of 1-BOC-3-aminopyrrolidine. LCMS (ESI) 343 (M+H) 1H NMR (400 MHz, ACETONITRILE-d3) δ ppm 10.54 (1H, s) 8.01 (1H, d, J=7.03 Hz) 7.67 (1H, d, J=5.27 Hz) 7.42 (1H, d, J=5.27 Hz) 7.39 (1H, dd, J=3.42, 1.85 Hz) 6.97 (1H, d, J=6.83 Hz) 6.66 (1H, dd, J=3.42, 1.66 Hz) 3.95 (1H, qd, J=6.80, 4.59 Hz) 3.72 (1H, dt, J=8.15, 6.56 Hz) 3.57-3.66 (1H, m) 3.29-3.48 (2H, m) 1.87-1.97 (3H, m) 1.77-1.86 (2H, m) 1.48-1.60 (1H, m)
Quellen und Nachweise
- ORD-Eintrag
- ord-16b4d1c067b54efbb13e06e2ade52c75
- Quelldatensatz
- uspto-grants-2015_05
- Patentnummer
- US09023847B2
Verknüpfte Notizen
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