1-Amino-2-propanol → 3-(1H-Pyrrolo[2,3-b]pyridin-4-ylamino)-thiophene-2-carboxylic acid (2-hydroxy-1-methyl-ethyl)-amide
Reaktionsgleichung
C(OC(N1C[CH2:11][CH:10]([NH:13][C:14]([C:16]2[S:17][CH:18]=[CH:19][C:20]=2[NH:21][C:22]2[CH:27]=[CH:26][N:25]=[C:24]3[NH:28][CH:29]=[CH:30][C:23]=23)=[O:15])[CH2:9]1)=O)(C)(C)C.NCC([OH:35])C>>[OH:35][CH2:9][CH:10]([NH:13][C:14]([C:16]1[S:17][CH:18]=[CH:19][C:20]=1[NH:21][C:22]1[CH:27]=[CH:26][N:25]=[C:24]2[NH:28][CH:29]=[CH:30][C:23]=12)=[O:15])[CH3:11]Komponenten
3
Versuchsvorschrift
This compound was prepared in an analogous manner as 3-{[3-(1H-Pyrrolo[2,3-b]pyridin-4-ylamino)-thiophene-2-carbonyl]-amino}-pyrrolidine-1-carboxylic acid tert-butyl ester using 1-amino-2-propanol instead of 1-BOC-3-aminopyrrolidine. LCMS (ESI) 317 (M+H) 1H NMR (400 MHz, DMSO-d6) δ ppm 11.52 (1H, s) 10.29 (1H, s) 8.01 (1H, d, J=5.47 Hz) 7.78 (1H, d, J=5.27 Hz) 7.69 (1H, d, J=8.00 Hz) 7.46 (1H, d, J=5.27 Hz) 7.27-7.33 (1H, m) 6.79 (1H, d, J=5.47 Hz) 6.43 (1H, dd, J=3.51, 1.95 Hz) 4.71 (1H, t, J=5.76 Hz) 3.97-4.09 (1H, m) 3.27-3.48 (2H, m) 1.09 (3H, d, J=6.64 Hz)
Quellen und Nachweise
- ORD-Eintrag
- ord-4fcd805a39eb49b59080379d7e312fbd
- Quelldatensatz
- uspto-grants-2015_05
- Patentnummer
- US09023847B2
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