HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Temozolomide → HCID 3352880, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Temozolomide | HCID 5394 | — |
| Edukt | 2,4-Bis(4-phenoxyphenyl)-2,4-dithioxo-1,3,2,4-dithiadiphosphetane | HCID 11813414 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | HCID 3352880 | HCID 3352880 | — |
Reaktionsschritte
A mixture of temozolomide (3 g, 15.5 mmol) and Belleau's reagent (4.49 g, 8.5 mmol) was refluxed in DCM (80 mL) overnight. The reaction was quenched with water and the precipitate was filtered and washed with diethyl ether to give the pure title compound as an orange solid. (2.75 g, 84%). δH, (DMSO-d6): 9.92 (1H, s), 9.45 (1H, s), 8.81 (1H, s), 3.85 (3H, s).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09024018B2 |
| Quelldatensatz | uspto-grants-2015_05 |
| ORD ID | ord-25cdbd6d9c284c5b9de55719f0c358de |
| Quellennotiz | uspto-grants-2015_05 |