Temozolomide → HCID 3352880, Verbindung

HRID 570921

Reaktionsgleichung

Reaktionsgleichung von HRID 570921
[CH3:1][N:2]1[N:11]=[N:10][C:9]2[N:5]([CH:6]=[N:7][C:8]=2[C:12]([NH2:14])=O)[C:3]1=[O:4].C1C=CC(OC2C=CC(P3(SP(C4C=CC(OC5C=CC=CC=5)=CC=4)(=S)S3)=[S:29])=CC=2)=CC=1>C(Cl)Cl>[CH3:1][N:2]1[C:3](=[O:4])[N:5]2[CH:6]=[N:7][C:8]([C:12](=[S:29])[NH2:14])=[C:9]2[N:10]=[N:11]1

Komponenten

4

Edukt 2

HCID 5394TemozolomideHCID 118134142,4-Bis(4-phenoxyphenyl)-2,4-dithioxo-1,3,2,4-dithiadiphosphetane

Produkt 1

HCID 3352880HCID 3352880, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of temozolomide (3 g, 15.5 mmol) and Belleau's reagent (4.49 g, 8.5 mmol) was refluxed in DCM (80 mL) overnight. The reaction was quenched with water and the precipitate was filtered and washed with diethyl ether to give the pure title compound as an orange solid. (2.75 g, 84%). δH, (DMSO-d6): 9.92 (1H, s), 9.45 (1H, s), 8.81 (1H, s), 3.85 (3H, s).

Aufarbeitung

  1. customThe reaction was quenched with water
  2. filtrationthe precipitate was filtered
  3. washwashed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-25cdbd6d9c284c5b9de55719f0c358de
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09024018B2

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