Ammonia → L-Glutamine

Beteiligte Stoffe

Reaktionsschritte

Alanylglutamine is prepared according to Chinese Patent CN1680428A. Wherein, N-α-chloropropionyl)-L-glutamine is synthesized first. Then, 0.12 g of the N-(α-chloropropionyl)-L-glutamine crystals containing two diastereomeric isomers and 300 mL of 28% aqueous ammonia are mixed in a reaction vessel under room temperature. The reaction is carried out under 60° C. temperature and 2 kg/cm2 pressure. L-Alanyl-L-glutamine crude product is obtained after workup procedures. TLC shows an Rf value of 0.14, with acetate:n-butanol:water (1:4:1) eluent and ninhydrin stain. The above L-alanyl-L-glutamine crude product is dissolved in water, charged with activated carbon, and stirred under room temperature. Then the activated carbon is filtered out, mother crystals are added into the solution, and the system is settled for a while.

Herkunft & Nachweise