Hydrochloric Acid → HCID 86681636, Verbindung

HRID 571220Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 571220
C(OC([NH:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:10]=1)=O)(C)(C)C.[ClH:24].O1CCOCC1>C(Cl)Cl>[ClH:24].[NH2:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:10]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 866816351H-Indole-1-acetic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-, ethyl ester

Produkt 1

HCID 86681636HCID 86681636, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of ethyl 2-(3-(tert-butoxycarbonylamino)-1H-indol-1-yl)acetate (275 mg, 0.864 mmol) in dry DCM (8 ml), cooled at 0° C. and under nitrogen, 4N HCl in dioxane (2.159 ml, 8.64 mmol) was added, and the mixture was stirred at room temperature for 36 hours. The solvent was removed under reduced pressure without heating to give ethyl 2-(3-amino-1H-indol-1-yl)acetate hydrochloride (220 mg, 0.864 mmol, quantitative yield). MS/ESI+ 219.1 [MH]+.

Aufarbeitung

  1. customThe solvent was removed under reduced pressure
  2. temperaturewithout heating

Quellen und Nachweise

ORD-Eintrag
ord-0ea932c3a3514d3f8ebba6a52bf77971
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09024027B2

Notizen zur Reaktion

Wird geladen…