Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])O[C:6]2=[O:15].[NH2:16][CH2:17][C:18]([OH:20])=[O:19]>C1(C)C=CC=CC=1>[CH3:13][O:12][C:11]1[CH:10]=[C:9]2[C:5](=[CH:4][C:3]=1[O:2][CH3:1])[C:6](=[O:15])[N:16]([CH2:17][C:18]([OH:20])=[O:19])[C:8]2=[O:14]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 180 °C
Versuchsvorschrift
A suspension of 5,6-dimethoxyisobenzofuran-1,3-dione (491 mg, 2.359 mmol) and 2-aminoacetic acid (195 mg, 2.59 mmol) in toluene (10 ml) was heated under MW irradiation at 180° C. for 7 hours. The precipitate was collected by filtration, washed with toluene (5 ml) and dried to afford 2-(5,6-dimethoxy-1,3-dioxoisoindolin-2-yl)acetic acid as a off-white powder (335 mg, 1.263 mmol, 54% yield). MS/ESI+ 265.9 [MH]+.
Aufarbeitung
- filtrationThe precipitate was collected by filtration
- washwashed with toluene (5 ml)
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-78e7d23c5932456880b4fb15ca7d3b07
- Quelldatensatz
- uspto-grants-2015_05
- Patentnummer
- US09024027B2
Verknüpfte Notizen
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