Aniline → (S)-tert-butyl 1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethylcarbamate

HRID 571996Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 571996
P([O-])(OC1C=CC=CC=1)OC1C=CC=CC=1.[NH2:17][C:18]1[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[C:19]=1[C:20]([OH:22])=O.[C:28]([O:32][C:33]([NH:35][C@@H:36]([CH3:40])[C:37](O)=O)=[O:34])([CH3:31])([CH3:30])[CH3:29].[NH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1>N1C=CC=CC=1.CCOC(C)=O>[Cl:27][C:23]1[CH:24]=[CH:25][CH:26]=[C:18]2[C:19]=1[C:20](=[O:22])[N:41]([C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)[C:37]([C@@H:36]([NH:35][C:33](=[O:34])[O:32][C:28]([CH3:31])([CH3:30])[CH3:29])[CH3:40])=[N:17]2

Komponenten

7

Edukt 4

HCID 6115AnilineHCID 750712-Amino-6-chlorobenzoic acidHCID 85082Tert-butoxycarbonylalanineHCID 23418553Diphenoxyphosphanolate

Produkt 1

HCID 86686186(S)-tert-butyl 1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethylcarbamate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1049PyridineLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

Diphenyl phosphite (1.9 mL, 10 mmol) was added to a solution of 2-amino-6-chlorobenzoic acid (495 mg, 2.9 mmol) and (S)-2-(tert-butoxycarbonylamino)propanoic acid (710 mg, 3.77 mmol) in pyridine (3 mL). The reaction mixture was stirred at 40° C. for 2 hours. Aniline (274 mg, 3.48 mmol) was then added to the reaction mixture, which was then stirred at 55° C. for 12 hours. The reaction mixture was cooled to room temperature. This mixture was then diluted with EtOAc (50 mL), washed with 1N aqueous HCl (2×50 mL), brine (50 mL), and dried over sodium sulfate. The organics layer was filtered and concentrated in vacuuo to afford material which was purified by column chromatography on SiO2 eluting with EtOAc in hexanes (0-50%) to afford (S)-tert-butyl 1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethylcarbamate as a solid. ES/MS m/z=400.1 (M+H+).

Aufarbeitung

  1. stirringwas then stirred at 55° C. for 12 hours
  2. temperatureThe reaction mixture was cooled to room temperature
  3. washwashed with 1N aqueous HCl (2×50 mL), brine (50 mL)
  4. dry with materialdried over sodium sulfate
  5. filtrationThe organics layer was filtered
  6. concentrationconcentrated in vacuuo
  7. customto afford material which
  8. customwas purified by column chromatography on SiO2 eluting with EtOAc in hexanes (0-50%)

Quellen und Nachweise

ORD-Eintrag
ord-3167d46642d64bab93e6606fb0e35063
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09029384B2

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