Methylamine → HCID 32890706, Verbindung

HRID 572692

Reaktionsgleichung

Reaktionsgleichung von HRID 572692
[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:13])[N:6]([CH2:8][C:9](OC)=[O:10])[CH:7]=1.[CH3:14][NH2:15]>C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:13])[N:6]([CH2:8][C:9]([NH:15][CH3:14])=[O:10])[CH:7]=1

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 28834262methyl 2-(5-bromo-2-oxopyridin-1(2H)-yl)acetate

Produkt 1

HCID 32890706HCID 32890706, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of methyl 2-(5-bromo-2-oxopyridin-1(2H)-yl)acetate (0.5 g, 1.92 mmol, WO 2009134400) in 2M solution of Methyl amine in THF (5 mL) was stirred at RT for 16 h. The separated solid is collected by filtration and dried under vacuum to afford 2-(5-bromo-2-oxopyridin-1(2H)-yl)-N-methylacetamide as off-white solid, 0.35 g (74%), 1H NMR (400 MHz, DMSO): 8.09 (1H, d, J=4.4 Hz), 7.93 (1H, d, J=2.4 Hz), 7.54 (1H, dd, J=3.0, 9.8 Hz), 6.36 (1H, d, J=9.8 Hz), 4.47 (2H, s), 2.61 (3H, d, J=4.9 Hz). ES-MS: 247.1 (M+2H).

Aufarbeitung

  1. filtrationThe separated solid is collected by filtration
  2. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-dd1d11926b3c4470b238918959edb734
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09029409B2

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