Methylamine → HCID 178483385, Verbindung

HRID 57282Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 57282
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17]Br)=[N:13][NH:12][C:11]=1[NH2:19].[CH3:20][NH2:21]>C1COCC1>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17][NH:21][CH3:20])=[N:13][NH:12][C:11]=1[NH2:19]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 178509116HCID 178509116, Verbindung

Produkt 1

HCID 178483385HCID 178483385, VerbindungAusbeute 32 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 4-benzothiazol-2-yl-5-(3-bromopropyl)-2H-pyrazol-3-ylamine (130 mg, 0.39 mmol) and methylamine (5 mL of a 2 M solution in THF, 10 mmol) was stirred at room temperature for 60 hrs. The resulting solid was isolated by filtration, washed with THF, and then with water. The product was air dried to yield 38 mg (32%) of the title compound as an off white solid. MS (m/z, ES+): 288.2 (M+1, 100%).

Aufarbeitung

  1. customThe resulting solid was isolated by filtration
  2. washwashed with THF
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a7b93501c10844e5a3d77d0eafb4e72b
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434720B2

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