Water → 3-Nitro-4-(1-(tetrahydro-2h-pyran-4-yl)piperidin-4-ylamino)benzenesulfonamide

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of EXAMPLE 49B (22.12 g), water (43 mL), and triethylamine (43.6 mL) in 1,4-dioxane (300 mL) was stirred at room temperature until EXAMPLE 49B completely dissolved. The solution was then treated with 4-chloro-3-nitrobenzenesulfonamide (20.3 g), heated at 90° C. for 16 hours, cooled and concentrated. 10% Methanol in dichloromethane was added, and the solution was stirred vigorously at room temperature until a fine suspension existed and then the mixture was filtered.

Herkunft & Nachweise