Potassium Phosphate, Tribasic → Ethyl 2-(4-amino-2-chlorophenoxy)-4-fluorobenzoate

HRID 573095

Reaktionsgleichung

Reaktionsgleichung von HRID 573095
F[C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[NH2:14][C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[C:17]([Cl:22])[CH:16]=1.[O-]P([O-])([O-])=O.[K+].[K+].[K+]>COCCOCCOC.C(OCC)(=O)C>[NH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][C:2]2[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=2[C:4]([O:6][CH2:7][CH3:8])=[O:5])=[C:17]([Cl:22])[CH:16]=1

Komponenten

6

Edukt 3

HCID 62657Potassium Phosphate, TribasicHCID 775784-Amino-2-chlorophenolHCID 2737170Benzoic acid, 2,4-difluoro-, ethyl ester

Produkt 1

HCID 67228057Ethyl 2-(4-amino-2-chlorophenoxy)-4-fluorobenzoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8150DiglymeLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

To a solution of ethyl 2,4-difluorobenzoate (6.48 g) and 4-amino-2-chlorophenol (5.0 g) in diglyme (40 mL) was added K3PO4 (7.39 g). The mixture was stirred at 110° C. overnight. The mixture was diluted with ethyl acetate (300 mL) and washed with water, brine and dried over Na2SO4. The mixture was filtered, and the solvent was evaporated and the residue was loaded on a column and eluted with 10% ethyl acetate in hexane to give the product.

Aufarbeitung

  1. washwashed with water, brine
  2. dry with materialdried over Na2SO4
  3. filtrationThe mixture was filtered
  4. customthe solvent was evaporated
  5. washeluted with 10% ethyl acetate in hexane
  6. customto give the product

Quellen und Nachweise

ORD-Eintrag
ord-788b9a1f586a424c98e346ebf676b9f6
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09029404B2

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