Piperazine → 2-[1-(4-Methoxy-benzyl)-1h-benzotriazol-4-yloxy]-4-piperazin-1-yl-benzoic acid methyl ester

HRID 573152Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 573152
[CH3:1][O:2][C:3](=[O:30])[C:4]1[CH:9]=[CH:8][C:7](F)=[CH:6][C:5]=1[O:11][C:12]1[C:20]2[N:19]=[N:18][N:17]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=3)[C:16]=2[CH:15]=[CH:14][CH:13]=1.[NH:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1.ClCCl>CS(C)=O>[CH3:1][O:2][C:3](=[O:30])[C:4]1[CH:9]=[CH:8][C:7]([N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)=[CH:6][C:5]=1[O:11][C:12]1[C:20]2[N:19]=[N:18][N:17]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=3)[C:16]=2[CH:15]=[CH:14][CH:13]=1

Komponenten

5

Edukt 3

HCID 4837PiperazineHCID 6344DichloromethaneHCID 672269974-Fluoro-2-[1-(4-methoxy-benzyl)-1h-benzotriazol-4-yloxy]-benzoic acid methyl ester

Produkt 1

HCID 672279252-[1-(4-Methoxy-benzyl)-1h-benzotriazol-4-yloxy]-4-piperazin-1-yl-benzoic acid methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a solution of EXAMPLE 342D (650 mg) in dimethylsulfoxide (12 mL) was added piperazine (618 mg). The solution was heated at 100° C. for one hour, cooled, added to dichloromethane, extracted with water three times, dried over anhydrous sodium sulfate, filtered, and the solvent was removed under vacuum.

Aufarbeitung

  1. temperaturecooled
  2. extractionextracted with water three times
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. customthe solvent was removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-e01668ef85de414bb9d5721f194a34c9
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09029404B2

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