Thionyl Chloride → 3-(Chloromethyl)-9h-pyrido[3,4-b]indole

HRID 574130

Reaktionsgleichung

Reaktionsgleichung von HRID 574130
O[CH2:2][C:3]1[N:4]=[CH:5][C:6]2[NH:7][C:8]3[C:13]([C:14]=2[CH:15]=1)=[CH:12][CH:11]=[CH:10][CH:9]=3.S(Cl)([Cl:18])=O>>[Cl:18][CH2:2][C:3]1[N:4]=[CH:5][C:6]2[NH:7][C:8]3[C:13]([C:14]=2[CH:15]=1)=[CH:12][CH:11]=[CH:10][CH:9]=3

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 53533383-Hydroxymethyl-beta-carboline

Produkt 1

HCID 201484093-(Chloromethyl)-9h-pyrido[3,4-b]indole

Versuchsvorschrift

The 3-(hydroxymethyl)-β-carboline was added to an excess (3 grams) of thionyl chloride and the mixture was refluxed for 1 hour. The excess thionyl chloride was then evaporated and the obtained residue was crystallized from hexane. 2.5 grams of 3-(chloromethyl)-β-carboline was obtained.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 1 hour
  2. customThe excess thionyl chloride was then evaporated
  3. customthe obtained residue was crystallized from hexane

Quellen und Nachweise

ORD-Eintrag
ord-8f092fbb1d3743d49827d0a3c9a91600
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09034872B2

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