4-tert-Butylcyclohexanone → 1-[4-(Tert-butyl)-1-cyclohexen-1-YL]pyrrolidine

HRID 574135

Reaktionsgleichung

Reaktionsgleichung von HRID 574135
[C:1]([CH:5]1[CH2:10][CH2:9][C:8](=O)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[NH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1>C1(C)C=CC=CC=1>[C:1]([CH:5]1[CH2:10][CH2:9][C:8]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 73924-tert-ButylcyclohexanoneHCID 31268Pyrrolidine

Produkt 1

HCID 1072321-[4-(Tert-butyl)-1-cyclohexen-1-YL]pyrrolidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A 50 mL round-bottomed flask containing 4-tert-butylcyclohexanone (6.01 gm) in anhydrous toluene (20 mL) was fitted with a Dean-Stark trap containing 3 A molecular sieves, reflux condenser and a heating mantle. Pyrrolidine (6.00 mL) was added, and the solution heated to reflux for 18 hr. The solvent was evaporated and the crude product was used directly for the next reaction.

Aufarbeitung

  1. customwas fitted with a Dean-Stark trap
  2. additioncontaining 3 A molecular sieves
  3. temperaturereflux condenser
  4. temperaturethe solution heated
  5. temperatureto reflux for 18 hr
  6. customThe solvent was evaporated
  7. customthe crude product was used directly for the next reaction

Quellen und Nachweise

ORD-Eintrag
ord-1dfc076b8c0246ffa08371707ff08b15
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09034871B2

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