HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → Ethyl 1-({amino[3-(trifluoromethyl)phenyl}acetyl]amino)cyclopropanecarboxylate hydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Ethyl 1-({[(tert-butoxycarbonyl)amino][3-(trifluoromethyl)phenyl]acetyl}amino)cyclopropanecarboxylate | HCID 66801809 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | Ethyl 1-({amino[3-(trifluoromethyl)phenyl}acetyl]amino)cyclopropanecarboxylate hydrochloride | HCID 89780476 | — |
Reaktionsschritte
262 mg (0.61 mmol) of the compound of Example 17A were dissolved in 4 ml of dichloromethane, and 4 ml of a 4N solution of hydrogen chloride in dioxane were added. The solution was stirred at RT for 3 h and then freed from the volatile components on a rotary evaporator. The residue was dried under high vacuum. This gave 223 mg (quant.) of the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09034855B2 |
| Quelldatensatz | uspto-grants-2015_05 |
| ORD ID | ord-63ef24af7ed74888b706354e023f6057 |
| Quellennotiz | uspto-grants-2015_05 |