Phenylboronic acid pinacol ester → (S)-2-[5-(3-Amino-6-methoxy-4-phenyl-5-trifluoromethyl-pyridin-2-yl)-[1,3,4]oxadiazol-2-yl]-1,1,1-trifluoro-propan-2-ol

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Phenylboronic acid pinacol ester	HCID 570673	—
Edukt	(S)-2-(5-(3-Amino-6-methoxy-5-(trifluoromethyl)-4-vinylpyridin-2-yl)-1,3,4-oxadiazol-2-yl)-1,1,1-trifluoropropan-2-ol	HCID 86729605	—
Produkt	(S)-2-[5-(3-Amino-6-methoxy-4-phenyl-5-trifluoromethyl-pyridin-2-yl)-[1,3,4]oxadiazol-2-yl]-1,1,1-trifluoro-propan-2-ol	HCID 71515863	—

Reaktionsschritte

The title compound was prepared analogously to (S)-2-(5-(3-Amino-6-methoxy-5-(trifluoromethyl)-4-vinylpyridin-2-yl)-1,3,4-oxadiazol-2-yl)-1,1,1-trifluoropropan-2-ol (Example 14.0 step 1) by replacing 4,4,5,5-tetramethyl-2-vinyl-1,3,2-dioxaborolane with 4,4,5,5-tetramethyl-2-phenyl-1,3,2-dioxaborolane;

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09034879B2
Quelldatensatz	uspto-grants-2015_05
ORD ID	ord-8075598c4eb64ffba214dad76997ea60
Quellennotiz	uspto-grants-2015_05