methyl 3-isothiocyanato-4-methylthiophene-2-carboxylate → HCID 178431853, Verbindung
Reaktionsgleichung
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[N:11]([C:14]1[C:18]([CH3:19])=[CH:17][S:16][C:15]=1[C:20](OC)=[O:21])=[C:12]=[S:13]>C1COCC1>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[C:20](=[O:21])[C:15]4[S:16][CH:17]=[C:18]([CH3:19])[C:14]=4[NH:11][C:12]3=[S:13])=[CH:9][C:4]=2[N:3]=[CH:2]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
1H-benzo[d]imidazol-5-amine (0.13 g, 0.98 mmol) and methyl 3-isothiocyanato-4-methylthiophene-2-carboxylate (0.21 g, 0.98 mmol) were dissolved in 10 mL of THF. The mixture was stirred by heating under reflux over night. The solvent was removed and the product was purified by means of semi-preparative HPLC.