4-[3-(Dimethylamino)propoxy]benzonitrile → 4-[3-(Dimethylamino)propoxy]benzylamine

HRID 574851Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 574851
[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=1>CO.[Ni]>[NH2:12][CH2:11][C:10]1[CH:9]=[CH:8][C:7]([O:6][CH2:5][CH2:4][CH2:3][N:2]([CH3:1])[CH3:15])=[CH:14][CH:13]=1

Komponenten

4

Edukt 1

HCID 118583624-[3-(Dimethylamino)propoxy]benzonitrile

Produkt 1

HCID 214653844-[3-(Dimethylamino)propoxy]benzylamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

4-(3-(Dimethylamino)propoxy)benzonitrile (300 mg) in methanol (20 mL) was treated with Raney nickel (wet, 1.5 g) under H2 (30 psi) for 4 hour. The insoluble material was filtered off and the filtrate was concentrated to provide the title compound.

Aufarbeitung

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-3e6a40bfeb16469da8fd64d469e0f5d1
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09034875B2

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