Potassium fluoride dihydrate → HCID 86669589, Verbindung
Reaktionsgleichung
[NH:1]1[CH:5]=[C:4]([C:6]([OH:14])([C:8]#[C:9][Si](C)(C)C)[CH3:7])[CH:3]=[N:2]1.O.O.[F-].[K+]>CO>[NH:1]1[CH:5]=[C:4]([C:6]([OH:14])([C:8]#[CH:9])[CH3:7])[CH:3]=[N:2]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
In a 20-mL sealed tube, a suspension of 2-(1H-pyrazol-4-yl)-4-(trimethylsilyl)but-3-yn-2-ol (1.4 g, 6.72 mmol, 1.00 equiv) and potassium fluoride dihydrate (2.0 g) in methanol (10 mL) was stirred for 1.5 h at 50° C. The resulting mixture was concentrated under vacuum. The resulting solution was diluted with 20 mL of water. The resulting solution was extracted with 3×20 mL of tetrahydrofuran/ethyl acetate (2/1) and the organic layers combined and dried over anhydrous sodium sulfate and concentrated under vacuum. This resulted in 1 g (98%) of 2-(1H-pyrazol-4-yl)but-3-yn-2-ol as a solid.