Dimethylamine → 4-((N,N-Dimethylamino)methyl)phenylboronic acid pinacol ester

HRID 57518

Reaktionsgleichung

Reaktionsgleichung von HRID 57518
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([B:9]2[O:13][C:12]([CH3:15])([CH3:14])[C:11]([CH3:17])([CH3:16])[O:10]2)=[CH:5][CH:4]=1.[NH:18]([CH3:20])[CH3:19]>C1COCC1>[CH3:19][N:18]([CH3:20])[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([B:9]2[O:13][C:12]([CH3:15])([CH3:14])[C:11]([CH3:17])([CH3:16])[O:10]2)=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 674DimethylamineHCID 37345062-(4-(Bromomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Produkt 1

HCID 34604594-((N,N-Dimethylamino)methyl)phenylboronic acid pinacol ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 2-(4-(bromomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (200 mg, 0.673 mmol) and aqueous Me2NH (4 mL) in THF (10 mL) was stirred at room temperature overnight. It was then concentrated under reduced pressure to give the title compound. MS (m/z): 262 (M+H)+.

Aufarbeitung

  1. concentrationIt was then concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-acbd8a8c17224c1387a500bd99a71009
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434726B2

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