(R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one → (R)-9-((3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)-N3-methyl-4,5-dihydrobenzo[b]pyrazol o[1,5-d][1,4]oxazepine-2,3-dicarboxamide

HRID 575304Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 575304
Br[C:2]1[CH:22]=[CH:21][C:5]2[O:6][CH2:7][CH2:8][C:9]3[N:10]([N:11]=[C:12]([C:18]([NH2:20])=[O:19])[C:13]=3[C:14]([NH:16][CH3:17])=[O:15])[C:4]=2[CH:3]=1.[C:23]([C@:25]1([OH:32])[CH2:29][CH2:28][N:27]([CH3:30])[C:26]1=[O:31])#[CH:24]>>[OH:32][C@@:25]1([C:23]#[C:24][C:2]2[CH:22]=[CH:21][C:5]3[O:6][CH2:7][CH2:8][C:9]4[N:10]([N:11]=[C:12]([C:18]([NH2:20])=[O:19])[C:13]=4[C:14]([NH:16][CH3:17])=[O:15])[C:4]=3[CH:3]=2)[CH2:29][CH2:28][N:27]([CH3:30])[C:26]1=[O:31]

Komponenten

3

Edukt 2

HCID 86693296(R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-oneHCID 866933369-bromo-N3-methyl-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2,3-dicarboxamide

Produkt 1

HCID 86693335(R)-9-((3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)-N3-methyl-4,5-dihydrobenzo[b]pyrazol o[1,5-d][1,4]oxazepine-2,3-dicarboxamideAusbeute 25 %

Versuchsvorschrift

Similar to as described in General Procedure G, 9-bromo-N3-methyl-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2,3-dicarboxamide was reacted with (R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one to give the titled compound as a brown solid (32 mg, 25%).

Quellen und Nachweise

ORD-Eintrag
ord-918ec120c7b8416cb69d6ee26822793f
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09034866B2

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