Metformin Hydrochloride → 1,3,5-Triazine-2,4-diamine, 3,6-dihydro-N2,N2,6-trimethyl-, hydrochloride (1:1)

HRID 575520

Reaktionsgleichung

Reaktionsgleichung von HRID 575520
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].[ClH:10].[CH3:11][CH:12]1OC(C)OC(C)O1>C(O)C(C)C.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>[ClH:10].[NH2:8][C:7]1[NH:6][C:4]([N:2]([CH3:3])[CH3:1])=[N:5][CH:11]([CH3:12])[N:9]=1

Komponenten

5

Edukt 2

HCID 14219Metformin HydrochlorideHCID 31264Paraldehyde

Produkt 1

HCID 101764861,3,5-Triazine-2,4-diamine, 3,6-dihydro-N2,N2,6-trimethyl-, hydrochloride (1:1)Ausbeute 183,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 521998p-Toluenesulfonic acid monohydrateKatalysatorHCID 6560IsobutanolLösungsmittel

Reaktionsbedingungen

Temperatur
12 °C

Versuchsvorschrift

Synthesis according to the invention: A mixture of 1002.6 g of metformin hydrochloride, 359.1 g of paraldehyde and 51.6 g of toluene-4-sulfonic acid monohydrate in 2405.9 g of isobutanol was heated under reflux for 6 hours. Some of the solvent was removed by distillation. The mixture was cooled to 12° C., and the white precipitate was separated off, giving 953.8 g (81.4%) of 4-amino-3,6-dihydro-2-dimethylamino-6-methyl-1,3,5-triazine hydrochloride.

Aufarbeitung

  1. customSynthesis
  2. temperaturewas heated
  3. temperatureunder reflux for 6 hours
  4. customSome of the solvent was removed by distillation
  5. customthe white precipitate was separated off

Quellen und Nachweise

ORD-Eintrag
ord-2cd48d6f605e40ae9c2565b7481c54c4
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09035048B2

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