Ethylene Glycol → 2-Hydroxyethyl ethyl(2-cyanoethyl)phosphinate
Reaktionsgleichung
[CH2:1]([P:3]([CH2:6][CH2:7][C:8]#[N:9])(=[O:5])[OH:4])[CH3:2].[CH2:10](O)[CH2:11][OH:12]>C1(C)C=CC=CC=1>[CH2:1]([P:3]([CH2:6][CH2:7][C:8]#[N:9])(=[O:4])[O:5][CH2:10][CH2:11][OH:12])[CH3:2]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
441 g (3.0 mol) of ethyl(2-cyanoethyl)phosphinic acid (produced as in Example 5) are at 85° C. dissolved in 400 ml of toluene and admixed with 248 g (4 mol) of ethylene glycol and esterified at about 100° C. in a distillation apparatus equipped with water trap during 4 h. On completion of the esterification the toluene and excess ethyl glycol is removed in vacuo to leave 510 g (89% of theory) of 2-hydroxyethyl ethyl-2-cyanoethylphosphinate as colorless oil.
Aufarbeitung
- customare at 85° C.
- customesterified at about 100° C. in a distillation apparatus
- customequipped with water trap during 4 h
- customOn completion of the esterification the toluene and excess ethyl glycol is removed in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-f75b77ce5d3b44678fb8bbaad6d32412
- Quelldatensatz
- uspto-grants-2015_05
- Patentnummer
- US09035088B2
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