Nitric Acid → HCID 86723852, Verbindung

HRID 576754Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 576754
S(=O)(=O)(O)O.[N+:6]([O-:9])(O)=[O:7].[CH3:10][C:11]1[N:16]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)[C:15](=[O:27])[N:14]([CH2:28][CH2:29][CH3:30])[C:13](=[O:31])[CH:12]=1>>[CH3:10][C:11]1[N:16]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)[C:15](=[O:27])[N:14]([CH2:28][CH2:29][CH3:30])[C:13](=[O:31])[C:12]=1[N+:6]([O-:9])=[O:7]

Komponenten

4

Edukt 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 867238536-methyl-3-propyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione

Produkt 1

HCID 86723852HCID 86723852, Verbindung

Versuchsvorschrift

To concentrated sulfuric acid (2.0 ml) were added in ice bath fuming nitric acid (0.2 ml), 6-methyl-3-propyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (prepared in Reference Example 21) (200.0 mg) and the resulting mixture was stirred for three hours in ice bath. The reaction mixture was poured into ice water, and the precipitated solids were collected by filtration to afford 6-methyl-5-nitro-3-propyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (219.0 mg).

Aufarbeitung

  1. filtrationthe precipitated solids were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-28131b9eaba448569b8c88b0db2516e2
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09040516B2

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