HCID 86723852, Verbindung → HCID 86723854, Verbindung

HRID 576755Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 576755
[CH3:1][C:2]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[C:6](=[O:18])[N:5]([CH2:19][CH2:20][CH3:21])[C:4](=[O:22])[C:3]=1[N+:23]([O-])=O>CO.O.[Pd]>[NH2:23][C:3]1[C:4](=[O:22])[N:5]([CH2:19][CH2:20][CH3:21])[C:6](=[O:18])[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:15])([F:17])[F:16])[CH:9]=2)[C:2]=1[CH3:1]

Komponenten

4

Edukt 1

HCID 86723852HCID 86723852, Verbindung

Produkt 1

HCID 86723854HCID 86723854, VerbindungAusbeute 103,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23219155Palladium hydrateKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 6-methyl-5-nitro-3-propyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (200.0 mg) in methanol (10.0 ml) was added palladium hydrate (20.0 mg) and the resulting mixture was stirred at room temperature under catalytic hydrogenation condition for twelve hours. The reaction mixture was degassed and then filtered through Celite (trade mark), and then concentrated under reduced pressure to afford 5-amino-6-methyl-3-propyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (190.0 mg).

Aufarbeitung

  1. customThe reaction mixture was degassed
  2. filtrationfiltered through Celite (trade mark)
  3. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-53d5553a1d2845848b6862db8fb1d171
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09040516B2

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