Hydrochloric Acid → HCID 66911325, Verbindung

HRID 57684Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 57684
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)[CH:5]=[CH:4][C:3]=1[C:19]#[N:20].[ClH:21]>O1CCOCC1>[ClH:21].[ClH:21].[NH2:1][C:2]1[C:3]([C:19]#[N:20])=[CH:4][CH:5]=[C:6]([NH:8][CH2:9][CH2:10][NH2:11])[N:7]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 57911763tert-Butyl{2-[(6-amino-5-cyanopyridin-2-yl)amino]ethyl}carbamate

Produkt 1

HCID 66911325HCID 66911325, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

6.76 g (24.38 mmol) of tert-butyl {2-[(6-amino-5-cyanopyridin-2-yl)amino]ethyl}carbamate (Example 29A) were dissolved in 122 ml of a 4N solution of hydrogen chloride in dioxane and the mixture was stirred for 30 min. The reaction mixture was concentrated to half of its original volume and the same amount of diethyl ether was added. The reaction mixture was stirred for 20 min and the product was filtered off and washed with diethyl ether. This gave 5.43 g (89% of theory) of the product as a solid.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated to half of its original volume
  2. additionthe same amount of diethyl ether was added
  3. stirringThe reaction mixture was stirred for 20 min
  4. filtrationthe product was filtered off
  5. washwashed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-ae72ff823466429994cce794b9ce5191
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434731B2

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