Phosphorus tribromide → 2-(Bromomethyl)-1-methyl-1H-benzimidazole--hydrogen bromide (1/1)

HRID 576993

Reaktionsgleichung

Reaktionsgleichung von HRID 576993
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:11]O.P(Br)(Br)[Br:14]>ClCCl>[BrH:14].[Br:14][CH2:11][C:3]1[N:2]([CH3:1])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=1

Komponenten

4

Edukt 2

HCID 24614Phosphorus tribromideHCID 344177(1-methyl-1H-1,3-benzodiazol-2-yl)methanol

Produkt 1

HCID 242294512-(Bromomethyl)-1-methyl-1H-benzimidazole--hydrogen bromide (1/1)

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of (1-methyl-1H-benzimidazol-2-yl)methanol (1.1 g, 6.8 mmol) in anhydrous dichloromethane (60 mL) was added dropwise phosphorus tribromide (1.3 mL, 14.0 mmol). The mixture was stirred at room temperature overnight. Dichloromethane was evaporated. The residue was dried in vacuo, affording 2-(bromomethyl)-1-methyl-1H-benzimidazole hydrobromide. The product was used without further purification.

Aufarbeitung

  1. customDichloromethane was evaporated
  2. customThe residue was dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-57f3301b836a4bb08298525512a33331
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09040538B2

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