Phosphorus tribromide → 4-(Bromomethyl)-3,5-dimethyl-1,2-oxazole

HRID 576996

Reaktionsgleichung

Reaktionsgleichung von HRID 576996
[CH3:1][C:2]1[C:6]([CH2:7]O)=[C:5]([CH3:9])[O:4][N:3]=1.P(Br)(Br)[Br:11]>ClCCl>[Br:11][CH2:7][C:6]1[C:2]([CH3:1])=[N:3][O:4][C:5]=1[CH3:9]

Komponenten

4

Edukt 2

HCID 24614Phosphorus tribromideHCID 2895753,5-Dimethyl-4-(hydroxymethyl)isoxazole

Produkt 1

HCID 127932894-(Bromomethyl)-3,5-dimethyl-1,2-oxazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of (3,5-dimethyl-1,2-oxazol-4-yl)methanol (805 mg, 6.3 mmol) in anhydrous dichloromethane (60 mL) was added dropwise phosphorus tribromide (1.2 mL, 12.6 mmol). The mixture was stirred at room temperature for 3 hours. Dichloromethane was evaporated, and the residue was dried in vacuo, affording 4-(bromomethyl)-3,5-dimethyl-1,2-oxazole. The product was used without further purification.

Aufarbeitung

  1. customDichloromethane was evaporated
  2. customthe residue was dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d389b342ecea4aac9787e12d8cb485cb
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09040538B2

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