Diethylamine → HCID 59589465, Verbindung

HRID 577011Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 577011
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]([Cl:12])=[C:7]([CH:11]=1)[C:8]([O-:10])=[O:9].[CH2:13]([NH:15][CH2:16][CH3:17])[CH3:14].[C:18](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:12][C:6]1[CH:5]=[CH:4][C:3]([CH2:2][N:15]([CH2:16][CH3:17])[CH2:13][CH3:14])=[CH:11][C:7]=1[C:8]([O:10][CH3:18])=[O:9]

Komponenten

5

Edukt 3

HCID 8021DiethylamineHCID 11430Potassium CarbonateHCID 86647906HCID 86647906, Verbindung

Produkt 1

HCID 59589465HCID 59589465, VerbindungAusbeute 99,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 5-(bromomethyl)-2-chlorobenzoate (4.0 g, 15.6 mmol), diethylamine (5 mL, 48.1 mmol), and potassium carbonate (4.3 g, 31.2 mmol) in acetone (60 mL) was stirred at room temperature for 2 days. The solid material was removed by filtration. The filtrate was recovered, evaporated, and dried in vacuo, affording methyl 2-chloro-5-[(diethylamino)methyl]benzoate (3.97 g, 99% yield). The product was used without further purification.

Aufarbeitung

  1. customThe solid material was removed by filtration
  2. customThe filtrate was recovered
  3. customevaporated
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5d22220758f14464b8a2b5343fd0f6dc
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09040538B2

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