Phosphorus tribromide → Benzenemethanamine, 3-(bromomethyl)-4-chloro-N,N-diethyl-

HRID 577013Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 577013
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]([CH2:12][CH3:13])[CH2:10][CH3:11])=[CH:4][C:3]=1[CH2:14]O.P(Br)(Br)[Br:17]>ClCCl>[Br:17][CH2:14][C:3]1[CH:4]=[C:5]([CH2:8][N:9]([CH2:12][CH3:13])[CH2:10][CH3:11])[CH:6]=[CH:7][C:2]=1[Cl:1]

Komponenten

4

Edukt 2

HCID 24614Phosphorus tribromideHCID 59589352HCID 59589352, Verbindung

Produkt 1

HCID 66815196Benzenemethanamine, 3-(bromomethyl)-4-chloro-N,N-diethyl-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of {2-chloro-5-[(diethylamino)methyl]phenyl}methanol (3.0 g, 13.2 mmol) in anhydrous dichloromethane (80 mL) was added dropwise phosphorus tribromide (2.5 mL, 26.4 mmol). The mixture was stirred at room temperature overnight. The solvent was evaporated. The residue was dried in vacuo, affording {[3-(bromomethyl)-4-chlorophenyl]methyl}diethylamine. The product was used without further purification.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customThe residue was dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d9abb775ec454232812831b90259a729
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09040538B2

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