Potassium Carbonate → HCID 178429521, Verbindung

HRID 577037Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 577037
Cl.[Cl:2][C:3]1[N:7]([CH3:8])[C:6]([CH2:9]Cl)=[N:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:17][C:18]1[N:23]=[C:22]([SH:24])[N:21]=[C:20]([OH:25])[CH:19]=1>CC(C)=O>[Cl:2][C:3]1[N:7]([CH3:8])[C:6]([CH2:9][S:24][C:22]2[N:21]=[C:20]([OH:25])[CH:19]=[C:18]([CH3:17])[N:23]=2)=[N:5][CH:4]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 123115195-chloro-2-(chloromethyl)-1-methyl-1H-imidazole hydrochlorideHCID 178429541HCID 178429541, Verbindung

Produkt 1

HCID 178429521HCID 178429521, VerbindungAusbeute 79 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

5-chloro-2-(chloromethyl)-1-methyl-1H-imidazole hydrochloride (1.0 g, 5.0 mmol), potassium carbonate (1.65 g, 12 mmol), and 6-methyl-2-sulfanylpyrimidin-4-ol (560 mg, 4.0 mmol) were mixed in acetone (20 mL). The mixture was stirred at room temperature overnight. Acetone was then removed under reduced pressure. The crude solid was purified by column chromatography to provide the title compound as a white solid (850 mg, 79% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.20 (s, 3H), 3.60 (s, 3H), 4.51 (s, 2H), 6.04 (br, 1H), 6.93 (s, 1H); M+ 271.

Aufarbeitung

  1. customAcetone was then removed under reduced pressure
  2. customThe crude solid was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-4aa706d1948e4be08531e647278a6beb
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09040538B2

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