Phosphorus tribromide → 3-(Bromomethyl)-2-ethylpyridine
Reaktionsgleichung
[CH2:1]([C:3]1[C:8]([CH2:9]O)=[CH:7][CH:6]=[CH:5][N:4]=1)[CH3:2].[Br:11]P(Br)Br>ClCCl>[Br:11][CH2:9][C:8]1[C:3]([CH2:1][CH3:2])=[N:4][CH:5]=[CH:6][CH:7]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution (2-ethylpyridin-3-yl)methanol (3.0 g, 21.9 mmol) in anhydrous dichloromethane (150 mL) was added tribromophosphane (2.3 mL, 24.2 mmol). The mixture was stirred at room temperature overnight. Dichloromethane was evaporated. The residue was dried in vacuo, affording 3-(bromomethyl)-2-ethylpyridine, which was used without further purification.
Aufarbeitung
- customDichloromethane was evaporated
- customThe residue was dried in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-cf8c9eaafa174db58dcb1e35d2908224
- Quelldatensatz
- uspto-grants-2015_05
- Patentnummer
- US09040538B2
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