HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethyl isothiocyanatoformate → Ethyl aminon-(3-bromopyridin-2-YL)methanethiocarbamate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethyl isothiocyanatoformate | HCID 85320 | — |
| Edukt | 2-Amino-3-bromopyridine | HCID 817700 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | Ethyl aminon-(3-bromopyridin-2-YL)methanethiocarbamate | HCID 59199107 | 100,1% |
Reaktionsschritte
To a solution of 2-amino-3-bromopyridine (50.0 g, 289 mmol, 1 equiv) in dichloromethane (500 mL) was added dropwise ethoxycarbonyl isothiocyanate (39.0 g, 297 mmol, 1.03 equiv) at room temperature. After 2 h, dichloromethane was removed in vacuo to provide crude ethyl [(3-bromopyridin-2-yl) carbamothioyl]carbamate (88 g).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09434732B2 |
| Quelldatensatz | uspto-grants-2016_09 |
| ORD ID | ord-3f38827b80af4bdb9a6ae3cdfa4213f7 |
| Quellennotiz | uspto-grants-2016_09 |