Hydrochloric Acid → 3-(2-(dimethylamino)ethoxy)-1-methyl-1H-pyrazole-5-carboxylic acid

HRID 577735

Reaktionsgleichung

Reaktionsgleichung von HRID 577735
[OH-].[K+].[CH3:3][N:4]([CH3:19])[CH2:5][CH2:6][O:7][C:8]1[CH:12]=[C:11]([C:13]([O:15]CC)=[O:14])[N:10]([CH3:18])[N:9]=1.Cl>CCO>[CH3:3][N:4]([CH3:19])[CH2:5][CH2:6][O:7][C:8]1[CH:12]=[C:11]([C:13]([OH:15])=[O:14])[N:10]([CH3:18])[N:9]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 86679667ethyl 3-(2-(dimethylamino)ethoxy)-1-methyl-1H-pyrazole-5-carboxylate

Produkt 1

HCID 866796683-(2-(dimethylamino)ethoxy)-1-methyl-1H-pyrazole-5-carboxylic acidAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

KOH (2.09 g, 37.4 mmol) was dissolved into EtOH (30 mL) and to this solution was added ethyl 3-(2-(dimethylamino)ethoxy)-1-methyl-1H-pyrazole-5-carboxylate (4.5 g, 18.7 mmol) and the mixture stirred at rt overnight. To the reaction mixture was added concentrated HCl (3.1 mL) with stirring and the resulting suspension was filtered and the cake was washed with EtOH (two×20 mL). The filtrate was concentrated to give the title compound (3.3 g, 83% yield) as a brown gum.

Aufarbeitung

  1. stirringwith stirring
  2. filtrationthe resulting suspension was filtered
  3. washthe cake was washed with EtOH (two×20 mL)
  4. concentrationThe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-4cbb75141e2b445bbc33bf5a0397755d
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09040547B2

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