Methanol → AC-Pro-ome

HRID 579825

Reaktionsgleichung

Reaktionsgleichung von HRID 579825
C[OH:2].[C:3]([N:6]1[CH2:10][CH2:9][CH:8]=[CH:7]1)(=[O:5])[CH3:4].[O:11]1[CH2:15]CC[CH2:12]1>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH3:12][O:11][C:15](=[O:2])[C@@H:7]1[CH2:8][CH2:9][CH2:10][N:6]1[C:3](=[O:5])[CH3:4]

Komponenten

5

Edukt 3

HCID 887MethanolHCID 8028TetrahydrofuranHCID 10909522N-Acetyl-2-pyrroline2×

Produkt 1

HCID 11019314AC-Pro-omeAusbeute 42,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 178418476HCID 178418476, VerbindungKatalysator

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A 70 mL stainless steel high pressure reactor having a Pyrex glass liner and a magnetic stir bar was charged with 5 mL of tetrahydrofuran, 0.5 mmol of n-pendadecane internal standard, 0.5 mmol of CH3OH, 35.1 mg of (PPh3)2PdCl2, and 56.6 mg of N-acetyl-2-pyrroline. The reactor was pressurized to 1000 psi with CO at room temperature, and the reaction mixture was stirred at 100° C. for 26 hours. Thereafter, the reactor was cooled to room temperature and vented to atmospheric pressure. The product mixture was analyzed by gas chromatography, and the analysis indicated 98.4% conversion of N-acetyl-2-pyrroline and 42.8% yield of N-acetylproline methyl ester.

Aufarbeitung

  1. customA 70 mL stainless steel high pressure reactor having
  2. customwas pressurized to 1000 psi with CO at room temperature
  3. temperatureThereafter, the reactor was cooled to room temperature

Quellen und Nachweise

ORD-Eintrag
ord-23c5847cc75b4d75b1676b3af4447543
Quelldatensatz
uspto-grants-1988_06
Patentnummer
US04749786

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