Methanol → AC-Pro-ome

HRID 579828

Reaktionsgleichung

Reaktionsgleichung von HRID 579828
CCCCCCCCCCCCCCC.C[OH:17].[C:18]([N:21]1[CH2:25][CH2:24][CH:23]=[CH:22]1)(=[O:20])[CH3:19].[O:26]1[CH2:30]CC[CH2:27]1>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH3:27][O:26][C:30](=[O:17])[C@@H:22]1[CH2:23][CH2:24][CH2:25][N:21]1[C:18](=[O:20])[CH3:19]

Komponenten

6

Edukt 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 12391PentadecaneHCID 10909522N-Acetyl-2-pyrroline2×

Produkt 1

HCID 11019314AC-Pro-omeAusbeute 25,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 178418476HCID 178418476, VerbindungKatalysator

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A 70 mL stainless steel high pressure reactor having a Pyrex glass liner and a magnetic stir bar was charged with 5 mL of tetrahydrofuran, 0.5 mmol of n-pentadecane internal standard, 0.75 mmol of CH3OH, 56.8 mg of (PPh3)2PdCl2, and 72.35 mg of N-acetyl-2-pyrroline. The reactor was pressurized with 1000 psi of CO and 300 psi of H2 at room temperature, and the reaction mixture was stirred at 100° C. for 18 hours. Thereafter, the reactor was cooled to room temperature and vented to atmospheric pressure. The product mixture was analyzed by gas chromatography, and the analysis indicated 100% conversion of N-acetyl-2-pyrroline and 25.2% yield of N-acetylproline methyl ester.

Aufarbeitung

  1. customA 70 mL stainless steel high pressure reactor having
  2. customwas pressurized with 1000 psi of CO and 300 psi of H2 at room temperature
  3. temperatureThereafter, the reactor was cooled to room temperature

Quellen und Nachweise

ORD-Eintrag
ord-393971dd9a944e91b90cd4b696449cac
Quelldatensatz
uspto-grants-1988_06
Patentnummer
US04749786

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