tert-Butanol → HCID 54182549, Verbindung

HRID 579830

Reaktionsgleichung

Reaktionsgleichung von HRID 579830
CCCCCCCCCCCCCCC.[C:16]([OH:20])([CH3:19])([CH3:18])[CH3:17].[C:21]([N:24]1[CH2:28][CH2:27][CH:26]=[CH:25]1)(=[O:23])[CH3:22].[O:29]1CCC[CH2:30]1>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[C:16]([O:20][C:30](=[O:29])[C@@H:25]1[CH2:26][CH2:27][CH2:28][N:24]1[C:21](=[O:23])[CH3:22])([CH3:19])([CH3:18])[CH3:17]

Komponenten

6

Edukt 4

HCID 6386tert-ButanolHCID 8028TetrahydrofuranHCID 12391PentadecaneHCID 10909522N-Acetyl-2-pyrroline2×

Produkt 1

HCID 54182549HCID 54182549, VerbindungAusbeute 1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 178418476HCID 178418476, VerbindungKatalysator

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A 70 mL stainless steel high pressure reactor having a Pyrex glass liner and a magnetic stir bar was charged with 5 mL of tetrahydrofuran, 0.5 mol of n-pentadecane internal standard, 0.5 mmol of tert-butyl alcohol, 40 mg of (PPh3)2PdCl2, and 55.5 mg of N-acetyl-2-pyrroline. The reactor was pressurized to 1000 psi with Co at room temperature, and the reaction mixture was stirred at 100° C. for 21 hours. Thereafter, the reactor was cooled to room temperature and vented to atmospheric pressure. The product mixture was analyzed by gas chromatography and mass spectrometry, and the analysis indicated 98.6% conversion of N-acetyl-2-pyrroline and 1.0% yield of N-acetylproline tert-butyl ester.

Aufarbeitung

  1. customA 70 mL stainless steel high pressure reactor having
  2. customwas pressurized to 1000 psi with Co at room temperature
  3. temperatureThereafter, the reactor was cooled to room temperature

Quellen und Nachweise

ORD-Eintrag
ord-813b2ab7835346c8897922047801d6e1
Quelldatensatz
uspto-grants-1988_06
Patentnummer
US04749786

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