HCID 20136772, Verbindung → 2-amino-5-isopropylbenzotrifluoride

HRID 579856Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 579856
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:12])[CH3:11])=[CH:6][C:5]=1[C:13]([F:16])([F:15])[F:14])([O-])=O>CO.[Ni]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:12])[CH3:11])=[CH:6][C:5]=1[C:13]([F:14])([F:15])[F:16]

Komponenten

4

Edukt 1

HCID 20136772HCID 20136772, Verbindung

Produkt 1

HCID 27752232-amino-5-isopropylbenzotrifluorideAusbeute 97,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

330 g of 2-nitro-5-isopropylbenzotrifluoride in 1,200 ml of methanol are initially introduced into a hydrogenation apparatus, and 30 g of Raney nickel are added. After the system has been flushed with hydrogen, a hydrogenation is carried out at 25°-45° C. under a pressure of 30 bar of hydrogen. After the hydrogen absorption is complete, the solution is filtered to separate off the catalyst. After the solvent has been distilled off, the product is distilled. 280 g of 2-amino-5-isopropylbenzotrifluoride (boiling point: 95°-8° C./18 mbar, nD20 : 1.4810) are obtained.

Aufarbeitung

  1. additionare added
  2. customAfter the system has been flushed with hydrogen
  3. customis carried out at 25°-45° C. under a pressure of 30 bar of hydrogen
  4. customAfter the hydrogen absorption
  5. filtrationthe solution is filtered
  6. customto separate off the catalyst
  7. distillationAfter the solvent has been distilled off
  8. distillationthe product is distilled

Quellen und Nachweise

ORD-Eintrag
ord-dfd5552c4a3344a79a6874cd30b81d7c
Quelldatensatz
uspto-grants-1988_06
Patentnummer
US04749813

Notizen zur Reaktion

Wird geladen…